Much is expected from the Portugal international, who signed for United from Sporting Lisbon for £47.7m this week.
He was picked to start in midfield for United and made an encouraging debut, even going close to scoring with a long-range free-kick that was well stopped by Wolves goalkeeper Rui Patrício.
But neither side could break the deadlock as both failed to further close the gap on fourth-place Chelsea.
Here are our player ratings.
Ratings: United vs Wolves
Show all 24
Take a look at the above gallery to see how we rated players from both teams.
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