Boris Johnson has been confirmed as the next prime minister as the result of the Tory leadership contest is announced.
Anne Milton, an education minister, resigned minutes before the announcement, saying she had “grave concerns” over Mr Johnson’s threats of a no-deal Brexit.
Other ministers are expected to follow suit before the new prime minister takes over from Theresa May tomorrow.
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The new Tory leader used his victory speech to promise he will “energise the country” and meet the 31 October Brexit deadline with a “new spirit of can-do”.
Mr Johnson secured more than two-thirds of the votes in the contest, comfortably defeating Jeremy Hunt, the foreign secretary..
In an apparent acknowledgement of his divisive style, Mr Johnson said: “I know that there will be people around the place who will question the wisdom of your decision.
“And there may even be some people here who still wonder quite what they have done.
“I would just point out to you of course nobody, no one party, no one person has a monopoly of wisdom. But if you look at the history of the last 200 years of this party’s existence you will see that it is we Conservatives who have had the best insights, I think, into human nature.”
Elsewhere, Labour’s ruling executive is due to meet for what will inevitably be a heated discussion on the party’s response to antisemitism.
David Gauke, the current justice secretary, has said he is confident there are "parliamentary mechanisms" to stop Boris Johnson forcing through a no-deal Brexit.
Mr Gauke, who has said he will not serve under Mr Johnson, insisted this would "not necessarily" involve bringing down the next government.
He told BBC Radio 4's Today:
"I think that there will be parliamentary mechanisms, if you like. There is a clear majority in the House of Commons that doesn't want to leave the EU without a deal, I think that will become very clear in the autumn."
"Are there circumstances where there is a risk of a government losing a confidence motion? Yes, clearly there are circumstances where there is a risk that that might happen. I think that the new prime minister would be wise to avoid getting into those circumstances."
Boris Johnson has arrived at his campaign HQ in Westminster, telling reporters he agreed with Jeremy Hunt, his rival, that it was "all to play for". Clearly no one has told the pair that, in fact, voting closed yesterday...
Michael Fallon, the former defence secretary, has insisted that Boris Johnson will be able to negotiate new concessions from the EU.
He told BBC Radio 4's Today:
"Nobody is aiming for no-deal, that is not the strategy. We want a better deal, parliament wants a better deal, and Boris Johnson has made clear throughout that he wants a better deal.
"But the way to get a better deal is to be very firm that that date is there in law.
"There are three months now before the end of October and it is perfectly possible, with plenty of goodwill on both sides, to improve the agreement so that Parliament does, in the end, support it."
Insisting the change in government could end the Brexit impasse, he added:
"Let sunshine win the day. Boris is optimistic about this, he is ambitious about this. We have three months to get wording that parliament will approve.
"I think you will find that a new government, a new mandate which Boris, I hope, will get this morning, a new focus, new ministers in charge, a fresh negotiating team - I think you will find that Brussels will not be unwilling to say 'OK, what are the points that you need to satisfy parliament on?'"
In case you were wondering, we're expecting the Tory leadership announcement to begin at 11.40am, with the actual result (after the inevitable preamble) set to be declared around 11.50am.
The winner - almost certainly Boris Johnson - will then give their first speech as Conservative leader.
They won't take over as prime minister until Wednesday, though. Tomorrow Theresa May will take her last session of PMQs before heading to Buckingham Palace to hand her resignation to the Queen.
The monarch will then summon the new prime minister for a short meeting before Mr Johnson (of, if there is a major upset, Jeremy Hunt...) heads to Downing Street to make a short statement before entering No10 for the first time as prime minister.
Jo Swinson, the new Liberal Democrat leader, has explicitly ruled out any future coalition with the Conservatives under Boris Johnson.
Asked by BBC Scotland whether the Lib Dems could form another coalition with the Tories at a future date, she said she was "crystal clear" that her party would not work with any party that supported Brexit.
During her last full day in office, Theresa May has appointed a Labour MP as an independent governmental adviser on antisemitism.
John Mann, who chairs the all-party parliamentary group on antisemitism and has been one of the most outspoken critics of Jeremy Corbyn's handling of the issue, will advise ministers on the best way to tackle anti-Jewish abuse.
Ms May said:
“Antisemitism is racism. It has absolutely no place in our society and we must fight its bitter scourge wherever it rears its head.
“I’ve been proud to lead a government that is tackling such discrimination in all its forms – from making sure courts have the powers they need to deal with those who peddle hatred, to asking the Law Commission to undertake a full review of hate crime legislation. But there is yet more to do.
“John Mann is, without exception, a key voice on this matter. He has frequently campaigned in the House of Commons on this issue and has tirelessly used his role as a politician to speak out on behalf of victims of anti-Jewish racism.
“I am confident he will bring the level of cross-party independent advice needed to advise government and to ensure we see progress on this very important issue.”
Jeremy Hunt and his wife have arrived at the QEII conference centre in Westminster where the result of the Conservative leadership contest will be announced in the next few minutes. He says he is feeling a "zen-like calm".
There is little suspense about the actual result of the Tory leadership contest, with Boris Johnson all but certain to win, but keep your eye on the margin of his victory.
If it is a resounding win - anything upwards of around two-thirds of the vote - he will have a mandate to do whatever he wants when he appoints his cabinet later this week. That means he would probably demote or sack more of his critics and rivals, possibly including leadership rival Jeremy Hunt. But if he wins by a slimmer margin, he is more likely to focus his efforts on trying to unify the Conservatives, possibly by giving the likes of Mr Hunt, or a cabinet Remainer, a plum job.