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Men who believe they can put off fatherhood and rely on IVF to have children have been given a reality check by research which suggests their fertility may drop off in a similar way to women before the menopause.
UK researchers found men in their fifties saw their chances of having a baby through IVF fall by a third compared to men in their mid-thirties. Women experience the menopause, on average, at the age of 51 after they stop producing eggs, but experts warn that a gradual build-up of damaging mutations in men’s sperm may produce a comparable effect.
This mechanism is thought to explain why rates of developmental disorders like autism are slightly higher in children who have older fathers, and researchers say more needs to be done to make men aware their fertility in old age is not guaranteed.
“Men’s sperm seems to be unaffected by their age right up to the age of 50, which is when there is a significant decline,” said Dr Guy Morris from the Centre for Reproductive and Genetic Health, which led the research along with University College London (UCL).
Health news in picturesShow all 40 1 /40Health news in pictures Health news in pictures Coronavirus outbreak The coronavirus Covid-19 has hit the UK leading to the deaths of two people so far and prompting warnings from the Department of Health
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Health news in pictures Thousands of emergency patients told to take taxi to hospital Thousands of 999 patients in England are being told to get a taxi to hospital, figures have showed. The number of patients outside London who were refused an ambulance rose by 83 per cent in the past year as demand for services grows
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Health news in pictures Vape related deaths spike A vaping-related lung disease has claimed the lives of 11 people in the US in recent weeks. The US Centre for Disease Control and Prevention has more than 100 officials investigating the cause of the mystery illness, and has warned citizens against smoking e-cigarette products until more is known, particularly if modified or bought “off the street”
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Health news in pictures Baldness cure looks to be a step closer Researchers in the US claim to have overcome one of the major hurdles to cultivating human follicles from stem cells. The new system allows cells to grow in a structured tuft and emerge from the skin
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Health news in pictures Junk food ads could be banned before watershed Junk food adverts on TV and online could be banned before 9pm as part of Government plans to fight the "epidemic" of childhood obesity. Plans for the new watershed have been put out for public consultation in a bid to combat the growing crisis, the Department of Health and Social Care (DHSC) said
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Health news in pictures Cancer breath test to be trialled in Britain The breath biopsy device is designed to detect cancer hallmarks in molecules exhaled by patients
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Health news in pictures Average 10 year old has consumed the recommended amount of sugar for an adult By their 10th birthdy, children have on average already eaten more sugar than the recommended amount for an 18 year old. The average 10 year old consumes the equivalent to 13 sugar cubes a day, 8 more than is recommended
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Health news in pictures Child health experts advise switching off screens an hour before bed While there is not enough evidence of harm to recommend UK-wide limits on screen use, the Royal College of Paediatrics and Child Health have advised that children should avoid screens for an hour before bed time to avoid disrupting their sleep
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Health news in pictures Daily aspirin is unnecessary for older people in good health, study finds A study published in the New England Journal of Medicine has found that many elderly people are taking daily aspirin to little or no avail
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Health news in pictures Vaping could lead to cancer, US study finds A study by the University of Minnesota's Masonic Cancer Centre has found that the carcinogenic chemicals formaldehyde, acrolein, and methylglyoxal are present in the saliva of E-cigarette users
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Health news in pictures More children are obese and diabetic There has been a 41% increase in children with type 2 diabetes since 2014, the National Paediatric Diabetes Audit has found. Obesity is a leading cause
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Health news in pictures Most child antidepressants are ineffective and can lead to suicidal thoughts The majority of antidepressants are ineffective and may be unsafe, for children and teenager with major depression, experts have warned. In what is the most comprehensive comparison of 14 commonly prescribed antidepressant drugs to date, researchers found that only one brand was more effective at relieving symptoms of depression than a placebo. Another popular drug, venlafaxine, was shown increase the risk users engaging in suicidal thoughts and attempts at suicide
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Health news in pictures Gay, lesbian and bisexual adults at higher risk of heart disease, study claims Researchers at the Baptist Health South Florida Clinic in Miami focused on seven areas of controllable heart health and found these minority groups were particularly likely to be smokers and to have poorly controlled blood sugar
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Health news in pictures Breakfast cereals targeted at children contain 'steadily high' sugar levels since 1992 despite producer claims A major pressure group has issued a fresh warning about perilously high amounts of sugar in breakfast cereals, specifically those designed for children, and has said that levels have barely been cut at all in the last two and a half decades
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Health news in pictures Potholes are making us fat, NHS watchdog warns New guidance by the National Institute for Health and Care Excellence (NICE), the body which determines what treatment the NHS should fund, said lax road repairs and car-dominated streets were contributing to the obesity epidemic by preventing members of the public from keeping active
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Health news in pictures New menopause drugs offer women relief from 'debilitating' hot flushes A new class of treatments for women going through the menopause is able to reduce numbers of debilitating hot flushes by as much as three quarters in a matter of days, a trial has found. The drug used in the trial belongs to a group known as NKB antagonists (blockers), which were developed as a treatment for schizophrenia but have been “sitting on a shelf unused”, according to Professor Waljit Dhillo, a professor of endocrinology and metabolism
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Health news in pictures Doctors should prescribe more antidepressants for people with mental health problems, study finds Research from Oxford University found that more than one million extra people suffering from mental health problems would benefit from being prescribed drugs and criticised “ideological” reasons doctors use to avoid doing so.
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Health news in pictures Student dies of flu after NHS advice to stay at home and avoid A&E The family of a teenager who died from flu has urged people not to delay going to A&E if they are worried about their symptoms. Melissa Whiteley, an 18-year-old engineering student from Hanford in Stoke-on-Trent, fell ill at Christmas and died in hospital a month later.
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Health news in pictures Government to review thousands of harmful vaginal mesh implants The Government has pledged to review tens of thousands of cases where women have been given harmful vaginal mesh implants.
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Health news in pictures Jeremy Hunt announces 'zero suicides ambition' for the NHS The NHS will be asked to go further to prevent the deaths of patients in its care as part of a “zero suicide ambition” being launched today
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Health news in pictures Human trials start with cancer treatment that primes immune system to kill off tumours Human trials have begun with a new cancer therapy that can prime the immune system to eradicate tumours. The treatment, that works similarly to a vaccine, is a combination of two existing drugs, of which tiny amounts are injected into the solid bulk of a tumour.
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Health news in pictures Babies' health suffers from being born near fracking sites, finds major study Mothers living within a kilometre of a fracking site were 25 per cent more likely to have a child born at low birth weight, which increase their chances of asthma, ADHD and other issues
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Health news in pictures NHS reviewing thousands of cervical cancer smear tests after women wrongly given all-clear Thousands of cervical cancer screening results are under review after failings at a laboratory meant some women were incorrectly given the all-clear. A number of women have already been told to contact their doctors following the identification of “procedural issues” in the service provided by Pathology First Laboratory.
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Health news in pictures More than 700 fewer nurses training in England in first year after NHS bursary scrapped The numbers of people accepted to study nursing in England fell 3 per cent in 2017, while the numbers accepted in Wales and Scotland, where the bursaries were kept, increased 8.4 per cent and 8 per cent respectively
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Health news in pictures Landmark study links Tory austerity to 120,000 deaths The paper found that there were 45,000 more deaths in the first four years of Tory-led efficiencies than would have been expected if funding had stayed at pre-election levels. On this trajectory that could rise to nearly 200,000 excess deaths by the end of 2020, even with the extra funding that has been earmarked for public sector services this year.
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Health news in pictures You cannot be fit and fat It is not possible to be overweight and healthy, a major new study has concluded. The study of 3.5 million Britons found that even “metabolically healthy” obese people are still at a higher risk of heart disease or a stroke than those with a normal weight range
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Health news in pictures Sleep deprivation When you feel particularly exhausted, it can definitely feel like you are also lacking in brain capacity. Now, a new study has suggested this could be because chronic sleep deprivation can actually cause the brain to eat itself
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Health news in pictures Exercise classes offering 45 minute naps launch David Lloyd Gyms have launched a new health and fitness class which is essentially a bunch of people taking a nap for 45 minutes. The fitness group was spurred to launch the ‘napercise’ class after research revealed 86 per cent of parents said they were fatigued. The class is therefore predominantly aimed at parents but you actually do not have to have children to take part
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Health news in pictures Babies born to fathers aged under 25 have higher risk of autism New research has found that babies born to fathers under the age of 25 or over 51 are at higher risk of developing autism and other social disorders. The study, conducted by the Seaver Autism Center for Research and Treatment at Mount Sinai, found that these children are actually more advanced than their peers as infants, but then fall behind by the time they hit their teenage years
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“Women lose the function of their reproductive organs when they go through the menopause. In men, the quality and quantity of sperm production declines with age and this seems to have a significant effect after the age of 50.”
Rod Stewart was 66 when his eighth child, Aiden, was born, and the silent film actor Charlie Chaplin had children into his seventies. But experts said these cases may be more down to the relatively wealthy men having much younger wives, and called for an awareness campaign to correct the myth that men can reproduce successfully into old age.
The UCL team analysed records from nearly 5,000 IVF cycles at the Centre for Reproductive and Genetic Health in London over the past nine years. The data, spanning 4,271 men, found that half of men under the age of 35 were able to get their partners pregnant, but by age 41 to 45 this had fallen to 35.1 per cent, and at age 51 success had slumped to just 30.5 per cent.
Previous studies have shown men’s chances of conceiving naturally drop off with age, but this study is one of the largest to look at success in IVF.
Professor Adam Balen, chair of the British Fertility Society Fertility Education Initiative, said: “We want to see fertility taught as part of the relationship and sex education curriculum and have been successful in getting it included. Young men need this information – they need to know that they won’t necessarily remain fertile their whole life and are more likely to have problems as they age.”
The findings were presented at the annual meeting of the European Society of Human Reproduction and Embryology in Vienna. However, experts believe there could be pressure to start applying these findings immediately.
There is currently no cut-off age for men to access IVF, though guidelines recommend that women should not be offered fertility treatment after the age of 42. Age could be added to weight, and a host of other criteria used, to restrict IVF access in England as budgets are squeezed.
“Commissioners want to see an upper age limit for men going to IVF as yet another way of rationing,” said Professor Allan Pacey, a fertility expert from the University of Sheffield. “I don’t think that’s justified because it’s a completely different biological mechanism – but commissioners want a number.”
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